The midfielder has played for Real since 2013, earning five Champions Leagues and three La Liga championships.
Casemiro will sign a four-year contract with an additional year’s option for an initial sum of £60 million plus £10 million in add-ons.
United, which is now last in the Premier League, will host Liverpool on Monday at Old Trafford.
After fulling his transfer, Casemiro will become one of Manchester United’s highest-paid players. He follows defender Lisandro Martinez, fullback Tyrell Malacia from Feyenoord, and midfielder Christian Eriksen as the club’s fourth acquisitions.
In an effort to strengthen Erik ten Hag’s midfield, United have shifted their focus to Casemiro after negotiations to buy Adrien Rabiot from Juventus fell through due to the player’s demands.
The pursuit of Barcelona player Frenkie de Jong by Manchester United is almost probably over after this agreement.
The club admits it is highly improbable they will land De Jong and Casemiro in the same transfer window, although not fully ruling out the possibility of doing so at some point in the future.
Casemiro won’t be able to play in Monday’s match against Liverpool since the transfer would be too late.
By comparing Casemiro’s stats to those of other center midfielders in La Liga last season, one can see the influence he had.
The Brazilian international finished first for blocks that were successful, second for tackles made behind Sergio Busquets of Barcelona, and third overall for possession gained. In the latter category, Mikel Merino of Real Sociedad won first place, with Busquets coming in second.
He assisted Real’s offense as well, placing seventh in the league among center midfielders for forward passes and joint-sixth for shoots.
In 2014–15, Casemiro spent a season on loan at Porto in Portugal before returning to Spain the following year as Real Madrid exercised his buy-back clause.
He has 222 appearances and 24 goals for the Spanish big players.